A multimodal study of a first episode psychosis cohort: potential markers of antipsychotic treatment resistance.

ABSTRACT: Treatment resistant (TR) psychosis is considered to be a significant cause of disability and functional impairment. Numerous efforts have been made to identify the clinical predictors of TR. However, the exploration of molecular and biological markers is still at an early stage. To understand the TR condition and identify potential molecular and biological markers, we analyzed demographic information, clinical data, structural brain imaging data, and molecular brain imaging data in 7 Tesla magnetic resonance spectroscopy from a first episode psychosis cohort that includes 136 patients. Age, gender, race, smoking status, duration of illness, and antipsychotic dosages were controlled in the analyses. We found that TR patients had a younger age at onset, more hospitalizations, more severe neg

SUBMITTER: Yang K 

PROVIDER: S-EPMC9001745 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature