Brain Network Topology and Structural-Functional Connectivity Coupling Mediate the Association Between Gut Microbiota and Cognition.

ABSTRACT: Increasing evidence indicates that gut microbiota can influence cognition via the gut-brain axis, and brain networks play a critical role during the process. However, little is known about how brain network topology and structural-functional connectivity (SC-FC) coupling contribute to gut microbiota-related cognition. Fecal samples were collected from 157 healthy young adults, and 16S amplicon sequencing was used to assess gut diversity and enterotypes. Topological properties of brain structural and functional networks were acquired by diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (fMRI data), and SC-FC coupling was further calculated. 3-Back, digit span, and Go/No-Go tasks were employed to assess cognition. Then, we tested for potential asso

SUBMITTER: Zhang S 

PROVIDER: S-EPMC9002058 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature