Causal Association Between Tea Consumption and Kidney Function: A Mendelian Randomization Study.

ABSTRACT:

Background

Causal research concerning the consumption of tea and the risk of chronic kidney disease (CKD) is limited. This study identified the potential causal effects of tea intake on CKD, the estimated glomerular filtration rate (eGFR), and albuminuria.

Methods

Genome-wide association studies (GWASs) from UK Biobank were able to identify single-nucleotide polymorphisms (SNPs) associated with an extra cup of tea each day. The summary statistics for the kidney function from the CKDGen consortium include 11,765 participants (12,385 cases of CKD) and 54,116 participants for the urinary albumin-to-creatinine ratio who were mostly of European descent. A two-sample Mendelian randomization (MR) analysis was performed to test the relationship between the selected SNPs and the risk

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9002236 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature