Vascular calcium signalling and ageing.

ABSTRACT: Changes in cellular Ca²⁺ levels have major influences on vascular function and blood pressure regulation. Vascular smooth muscle cells (SMCs) and endothelial cells (ECs) orchestrate vascular activity in distinct ways, often involving highly specific fluctuations in Ca²⁺ signalling. Ageing is a major risk factor for cardiovascular diseases, but the impact of ageing per se on vascular Ca²⁺ signalling has received insufficient attention. We reviewed the literature for age-related changes in Ca²⁺ signalling in relation to vascular structure and function. Vascular tone dysregulation in several vascular beds has been linked to abnormal expression or activity of SMC voltage-gated Ca²⁺ channels, Ca²⁺ -activated K⁺ channel

SUBMITTER: Harraz OF 

PROVIDER: S-EPMC9002240 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature