The Survival Impact of Second Primary Lung Cancer in Patients With Lung Cancer.

ABSTRACT:

Background

Lung cancer survivors have a high risk of developing second primary lung cancer (SPLC), but little is known about the survival impact of SPLC diagnosis.

Methods

We analyzed data from 138 969 patients in the Surveillance, Epidemiology, and End Results (SEER), who were surgically treated for initial primary lung cancer (IPLC) in 1988-2013. Each patient was followed from the date of IPLC diagnosis to SPLC diagnosis (for those with SPLC) and last vital status through 2016. We performed multivariable Cox regression to evaluate the association between overall survival and SPLC diagnosis as a time-varying predictor. To investigate potential effect modification, we tested interaction between SPLC and IPLC stage. Using data from the Multiethnic Cohort Study (MEC) (n = 1540

SUBMITTER: Choi E 

PROVIDER: S-EPMC9002287 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature