Association of Birth Defects With Child Mortality Before Age 14 Years.

ABSTRACT:

Importance

Causes of death in children with birth defects are poorly understood.

Objective

To determine mortality rates by cause of death in children with and without birth defects.

Design, setting, and participants

This longitudinal cohort study included a population-based sample of 1 037 688 children and was conducted in all hospitals in Quebec, Canada, with 7 700 596 person-years of follow-up between birth and age 14 years (April 1, 2006, to March 31, 2020).

Exposures

Presence or absence of a birth defect.

Main outcomes and measures

Outcomes were all-cause and cause-specific mortality. Hazard ratios (HRs) and 95% CIs were computed for the association between birth defects and mortality with Cox proportional hazards models adjusted for patient characte

SUBMITTER: Sattolo ML 

PROVIDER: S-EPMC9002336 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature