Influences of Vitamin B₁₂ Supplementation on Cognition and Homocysteine in Patients with Vitamin B₁₂ Deficiency and Cognitive Impairment.

ABSTRACT: Vitamin B₁₂ deficiency is associated with cognitive impairment, hyperhomocysteinemia, and hippocampal atrophy. However, the recovery of cognition with vitamin B₁₂ supplementation remains controversial. Of the 1716 patients who visited our outpatient clinic for dementia, 83 had vitamin B₁₂ deficiency. Among these, 39 patients (mean age, 80.1 ± 8.2 years) had undergone Mini-Mental State Examination (MMSE) and laboratory tests for vitamin B₁₂, homocysteine (Hcy), and folic acid levels. The hippocampal volume was estimated using the z-score of the MRI-voxel-based specific regional analysis system for Alzheimer's disease. This is multi-center, open-label, single-arm study. All the 39 patients were administered vitamin B₁₂ and underwent reas

SUBMITTER: Ueno A 

PROVIDER: S-EPMC9002374 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature