Systematic Analysis of the Molecular Mechanisms of Cold and Hot Properties of Herbal Medicines.

ABSTRACT: Effective treatments for patients experiencing temperature-related symptoms are limited. The hot and cold effects of traditional herbal medicines have been utilized to treat and manage these symptoms, but their molecular mechanisms are not fully understood. Previous studies with arbitrarily selected herbs and ingredients may have produced biased results. Here, we aim to systematically elucidate the molecular mechanisms of the hot and cold properties of herbal medicines through an unbiased large-scale investigation of herbal ingredients, their target genes, and the transcriptome signatures induced by them. Using data regarding 243 herbs retrieved from two herbal medicine databases, we statistically identify (R)-Linalool, (-)-alpha-pinene, peruviol, (L)-alpha-terpineol, and cymol as five new

SUBMITTER: Park SM 

PROVIDER: S-EPMC9002596 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature