The Pandemic Response Box─Accelerating Drug Discovery Efforts after Disease Outbreaks.

ABSTRACT: The current Covid-19 pandemic has underlined the need for a more coordinated and forward-looking investment in the search for new medicines targeting emerging health care threats. Repositioning currently approved drugs is a popular approach to any new emerging disease, but it represents a first wave of response. Behind this would be a second wave of more specifically designed therapies based on activities against specific molecular targets or in phenotypic assays. Following the successful deployment and uptake of previous open access compound collections, we assembled the Pandemic Response Box, a collection of 400 compounds to facilitate drug discovery in emerging infectious disease. These are based on public domain information on chemotypes currently in discovery and early development whi

SUBMITTER: Samby K 

PROVIDER: S-EPMC9003238 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature