Efficacy and Mechanisms of Copper Ion-Catalyzed Inactivation of Human Norovirus.

ABSTRACT: The antinoroviral effect of copper ions is well known, yet most of this work has previously been conducted in copper and copper alloy surfaces, not copper ions in solution. In this work, we characterized the effects that Cu ions have on human norovirus capsids' and surrogates' integrity to explain empirical data, indicating virus inactivation by copper alloy surfaces, and as means of developing novel metal ion-based virucides. Comparatively high concentrations of Cu(II) ions (>10 mM) had little effect on the infectivity of human norovirus surrogates, so we used sodium ascorbate as a reducing agent to generate unstable Cu(I) ions from solutions of copper bromide. We found that significantly lower concentrations of monovalent copper ions (∼0.1 mM) compared to divalent copper ions cause capsi

SUBMITTER: Mertens BS 

PROVIDER: S-EPMC9003239 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature