Leptin Levels of the Perinatal Period Shape Offspring's Weight Trajectories through the First Year of Age.

ABSTRACT: Leptin is a hormone regulating lifetime energy homeostasis and metabolism and its concentration is important starting from prenatal life. We aimed to investigate the association of perinatal leptin concentrations with growth trajectories during the first year of life. Prospective, longitudinal study, measuring leptin concentration in maternal plasma before delivery, cord blood (CB), and mature breast milk and correlating their impact on neonate's bodyweight from birth to 1 year of age, in 16 full-term (FT), 16 preterm (PT), and 13 intrauterine growth-restricted (IUGR) neonates. Maternal leptin concentrations were highest in the PT group, followed by IUGR and FT, with no statistical differences among groups (p = 0.213). CB leptin concentrations were significantly higher in FT compared with

SUBMITTER: Garofoli F 

PROVIDER: S-EPMC9003253 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature