Signaling Pathways and Targeted Therapies for Stem Cells in Prostate Cancer.

ABSTRACT: Prostate cancer (PCa) is one of the most frequently occurring cancers among men, and the current statistics show that it is the second leading cause of cancer-related deaths among men. Over the years, research in PCa treatment and therapies has made many advances. Despite these efforts, the standardized therapies such as radiation, chemotherapy, hormonal therapy and surgery are not considered completely effective in treating advanced and metastatic PCa. In most situations, fast-dividing tumor cells are targeted, leaving behind relatively slowly dividing, chemoresistant cells known as cancer stem cells. Therefore, following the seemingly successful treatments, the lingering quiescent cancer stem cells are able to renew themselves, undergo differentiation into mature tumor cells, and suffici

SUBMITTER: Giridharan M 

PROVIDER: S-EPMC9003388 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature