Rotating night shift work and risk of multiple sclerosis in the Nurses' Health Studies.

ABSTRACT:

Objectives

Night shift work has been suggested as a possible risk factor for multiple sclerosis (MS). The objective of the present analysis was to prospectively evaluate the association of rotating night shift work history and MS risk in two female cohorts, the Nurses' Health Study (NHS) and NHSII.

Methods

A total of 83 992 (NHS) and 114 427 (NHSII) women were included in this analysis. We documented 579 (109 in NHS and 470 in NHSII) incident physician-confirmed MS cases (moderate and definite diagnosis), including 407 definite MS cases. The history (cumulative years) of rotating night shifts (≥3 nights/month) was assessed at baseline and updated throughout follow-up. Cox proportional hazards models were used to estimate HRs and 95% CIs for the association between rotating n

SUBMITTER: Papantoniou K 

PROVIDER: S-EPMC9003570 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature