CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression.

ABSTRACT: Metastasis is the major cause of cancer-related deaths due to the lack of effective therapies. Emerging evidence suggests that certain epigenetic and transcriptional regulators drive cancer metastasis and could be targeted for metastasis treatment. To identify epigenetic regulators of breast cancer metastasis, we profiled the transcriptomes of matched pairs of primary breast tumors and metastases from human patients. We found that distant metastases are more immune inert with increased M2 macrophages compared to their matched primary tumors. The acetyl-lysine reader, cat eye syndrome chromosome region candidate 2 (CECR2), was the top up-regulated epigenetic regulator in metastases associated with an increased abundance of M2 macrophages and worse metastasis-free survival. CECR2 was require

SUBMITTER: Zhang M 

PROVIDER: S-EPMC9003667 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature