Plasma disappearance rate of albumin when infused as a 20% solution.

ABSTRACT:

Background

The transcapillary leakage of albumin is increased by inflammation and major surgery, but whether exogenous albumin also disappears faster is unclear.

Methods

An intravenous infusion of 3 mL/kg of 20% albumin was given over 30 min to 70 subjects consisting of 15 healthy volunteers, 15 post-burn patients, 15 patients who underwent surgery with minor bleeding, 10 who underwent surgery with major bleeding (mean, 1.1 L) and 15 postoperative patients. Blood Hb and plasma albumin were measured on 15 occasions over 5 h. The rate of albumin disappearance from the plasma was quantitated with population kinetic methodology and reported as the half-life (T_1/2).

Results

No differences were observed for T_1/2 between volunteers, post-burn patients,

SUBMITTER: Zdolsek M 

PROVIDER: S-EPMC9003982 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature