Engineering defected 2D Pd/H-TiO₂ nanosonosensitizers for hypoxia alleviation and enhanced sono-chemodynamic cancer nanotherapy.

ABSTRACT:

Background

Sonodynamic therapy (SDT) is a burgeoning modality for cancer therapy owing to its high tissue-penetrating capability, controllability and safety. Whereas, the undesirable reactive oxygen species (ROS) yield of sonosensitizers and tumor hypoxia are two vulnerable spots of SDT. Therefore, it is an advisable strategy to augment ROS level and simultaneously relieve hypoxia for SDT to arrive its full potential in cancer treatment.

Results

In this work, the defected two-dimensional (2D) Pd/H-TiO₂ nanosheets (NSs) with triple antineoplastic properties were dexterously elaborated and engineered using a facile one-pot Pd-catalyzed hydrogenation tactic by loading a tiny amount of Pd and then inletting hydrogen flow at atmospheric pressure and temperature. The 2D

SUBMITTER: Qiao X 

PROVIDER: S-EPMC9003983 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature