A novel Vascular Leak Index identifies sepsis patients with a higher risk for in-hospital death and fluid accumulation.

ABSTRACT:

Purpose

Sepsis is a leading cause of morbidity and mortality worldwide and is characterized by vascular leak. Treatment for sepsis, specifically intravenous fluids, may worsen deterioration in the context of vascular leak. We therefore sought to quantify vascular leak in sepsis patients to guide fluid resuscitation.

Methods

We performed a retrospective cohort study of sepsis patients in four ICU databases in North America, Europe, and Asia. We developed an intuitive vascular leak index (VLI) and explored the relationship between VLI and in-hospital death and fluid balance using generalized additive models (GAM).

Results

Using a GAM, we found that increased VLI is associated with an increased risk of in-hospital death. Patients with a VLI in the highest quartile (Q4),

SUBMITTER: Chandra J 

PROVIDER: S-EPMC9003991 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature