Association Between Copper and Global Cognition and the Moderating Effect of Iron.

ABSTRACT:

Background

Despite the known association between abnormal serum copper levels and Alzheimer's disease (AD) or cognitive decline, the association between copper, iron, and cognition remains poorly investigated. We examined the association between serum copper levels and global cognition measured using the Mini-Mental State Examination (MMSE) in older adults with normal copper levels. We also explored the moderating effect of iron on this association.

Methods

The study enrolled 99 non-demented adults between 65 and 90 years of age. All the participants underwent comprehensive clinical assessments and serum copper measurements. Global cognitive performance was measured by the MMSE. All copper levels were within the normal range and were stratified into three categories: < 87 (l

SUBMITTER: Choe YM 

PROVIDER: S-EPMC9003994 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature