Preclinical safety and hepatotoxicity evaluation of biomineralized copper sulfide nanoagents.

ABSTRACT: Albumin-biomineralized copper sulfide nanoparticles (Cu_2-xS NPs) have attracted much attention as an emerging phototheranostic agent due to their advantages of facile preparation method and high biocompatibility. However, comprehensive preclinical safety evaluation is the only way to meet its further clinical translation. We herein evaluate detailedly the safety and hepatotoxicity of bovine serum albumin-biomineralized Cu_2-xS (BSA@Cu_2-xS) NPs with two different sizes in rats. Large-sized (LNPs, 17.8 nm) and small-sized (SNPs, 2.8 nm) BSA@Cu_2-xS NPs with great near-infrared absorption and photothermal conversion efficiency are firstly obtained. Seven days after a single-dose intravenous administration, SNPs distributed throughout the body are clea

SUBMITTER: Xia YN 

PROVIDER: S-EPMC9004045 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature