Repair-related molecular changes during recovery phase of ischemic stroke in female rats.

ABSTRACT:

Background

Some degree of spontaneous recovery is usually observed after stroke. Experimental studies have provided information about molecular mechanisms underlying this recovery. However, the majority of pre-clinical stroke studies are performed in male rodents, and females are not well studied. This is a clear discrepancy when considering the clinical situation. Thus, it is important to include females in the evaluation of recovery mechanisms for future therapeutic strategies. This study aimed to evaluate spontaneous recovery and molecular mechanisms involved in the recovery phase two weeks after stroke in female rats.

Methods

Transient middle cerebral artery occlusion was induced in female Wistar rats using a filament model. Neurological functions were assessed up to day

SUBMITTER: Mostajeran M 

PROVIDER: S-EPMC9004052 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature