Environmental factors associated with juvenile idiopathic inflammatory myopathy clinical and serologic phenotypes.

ABSTRACT:

Background

Environmental exposures have been associated with the juvenile idiopathic inflammatory myopathies (JIIM). We undertook a questionnaire-based study to evaluate patient-reported exposures as possible risk factors for JIIM.

Findings

One-hundred-seven patients with JIIM were enrolled in a myositis natural history protocol and completed environmental questionnaires. Frequencies of exposures in clinical and myositis-specific autoantibody (MSA) groups were examined. Patients with juvenile dermatomyositis (JDM) and juvenile connective tissue myositis (JCTM) more frequently received an immunization within 1 year of diagnosis compared to juvenile polymyositis (57.5 and 71.4% vs 0.0%, p ≤ 0.017). JCTM patients were more often underweight at diagnosis relative to JDM patients

SUBMITTER: Scalabrini JC 

PROVIDER: S-EPMC9004071 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature