Cysteine-rich protein 2 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in mice.

ABSTRACT:

Background

Abdominal aortic aneurysm (AAA) is a relatively common and often fatal condition. A major histopathological hallmark of AAA is the severe degeneration of aortic media with loss of vascular smooth muscle cells (VSMCs), which are the main source of extracellular matrix (ECM) proteins. VSMCs and ECM homeostasis are essential in maintaining structural integrity of the aorta. Cysteine-rich protein 2 (CRP2) is a VSMC-expressed protein; however, the role of CRP2 in AAA formation is unclear.

Methods

To investigate the function of CRP2 in AAA formation, mice deficient in Apoe (Apoe^-/-) or both CRP2 (gene name Csrp2) and Apoe (Csrp2^-/-Apoe^-/-) were subjected to an angiotensin II (Ang II) infusion model of AAA formation. Aortas were harvested

SUBMITTER: Chen CH 

PROVIDER: S-EPMC9004090 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature