Growth factor independence underpins a paroxysmal, aggressive Wnt5a^High/EphA2^Low phenotype in glioblastoma stem cells, conducive to experimental combinatorial therapy.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is an incurable tumor, with a median survival rate of only 14-15 months. Along with heterogeneity and unregulated growth, a central matter in dealing with GBMs is cell invasiveness. Thus, improving prognosis requires finding new agents to inhibit key multiple pathways, even simultaneously. A subset of GBM stem-like cells (GSCs) may account for tumorigenicity, representing, through their pathways, the proper cellular target in the therapeutics of glioblastomas. GSCs cells are routinely enriched and expanded due to continuous exposure to specific growth factors, which might alter some of their intrinsic characteristic and hide therapeutically relevant traits.

Methods

By removing exogenous growth factors stimulation, here we isolated and

SUBMITTER: Trivieri N 

PROVIDER: S-EPMC9004109 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature