Identification of Aloe-derived natural products as prospective lead scaffolds for SARS-CoV-2 main protease (M^pro) inhibitors.

ABSTRACT: In the past two years, the COVID-19 pandemic has caused over 5 million deaths and 250 million infections worldwide. Despite successful vaccination efforts and emergency approval of small molecule therapies, a diverse range of antivirals is still needed to combat the inevitable resistance that will arise from new SARS-CoV-2 variants. The main protease of SARS-CoV-2 (M^pro) is an attractive drug target due to the clinical success of protease inhibitors against other viruses, such as HIV and HCV. However, in order to combat resistance, various chemical scaffolds need to be identified that have the potential to be developed into potent inhibitors. To this end, we screened a high-content protease inhibitor library against M^proin vitro, in order to identify structurally dive

SUBMITTER: Hicks EG 

PROVIDER: S-EPMC9004148 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature