Evaluations of candidate markers of dihydroartemisinin-piperaquine resistance in Plasmodium falciparum isolates from the China-Myanmar, Thailand-Myanmar, and Thailand-Cambodia borders.

ABSTRACT:

Background

The fast-declining clinical efficacy of dihydroartemisinin-piperaquine (DHA-PPQ) in Cambodia is a warning of the underlying westward dissemination of piperaquine resistance in the Greater Mekong Subregion (GMS). Mutations in the Plasmodium falciparum Kelch 13-propeller (PfK13) and the P. falciparum chloroquine resistance transporter (PfCRT), as well as plasmepsin 2/3 gene amplification, have been discovered as molecular markers for predicting DHA-PPQ treatment failure. Determining whether these genetic variations of P. falciparum are linked to DHA-PPQ resistance is critical, especially along the China-Myanmar (CM) border, where PPQ has been utilized for decades.

Methods

A total of 173 P. falciparum samples of dried blood spots (DBS) were collected along the CM bor

SUBMITTER: Ye R 

PROVIDER: S-EPMC9004172 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature