Double-activation of mitochondrial permeability transition pore opening via calcium overload and reactive oxygen species for cancer therapy.

ABSTRACT:

Background

Calcium ions (Ca²⁺) participates in various intracellular signal cascades and especially plays a key role in pathways relevant to cancer cells. Mitochondrial metabolism stimulated by calcium overload can trigger the opening of the mitochondrial permeability transition pore (MPTP), which leads to cancer cell death.

Methods

Herein, a mitochondrial pathway for tumour growth inhibition was built via the double-activation of MPTP channel. Fe²⁺ doped covalent organic frameworks (COF) was synthesised and applied as template to grow CaCO₃ shell. Then O₂ was storaged into Fe²⁺ doped COF, forming O₂-FeCOF@CaCO₃ nanocomposite. After modification with folic acid (FA), O₂-FeCOF@CaCO_3</

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC9004178 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature