Dynamics of the infant gut microbiota in the first 18 months of life: the impact of maternal HIV infection and breastfeeding.

ABSTRACT:

Background

Access to antiretroviral therapy (ART) during pregnancy and breastfeeding for mothers with HIV has resulted in fewer children acquiring HIV peri- and postnatally, resulting in an increase in the number of children who are exposed to the virus but are not infected (HEU). HEU infants have an increased likelihood of childhood infections and adverse growth outcomes, as well as increased mortality compared to their HIV-unexposed (HUU) peers. We explored potential differences in the gut microbiota in a cohort of 272 Nigerian infants born to HIV-positive and negative mothers in this study during the first 18 months of life.

Results

The taxonomic composition of the maternal vaginal and gut microbiota showed no significant differences based on HIV status, and the compositi

SUBMITTER: Grant-Beurmann S 

PROVIDER: S-EPMC9004197 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature