Association between PNPLA3 rs738409 G variant and MRI cerebrovascular disease biomarkers.

ABSTRACT:

Introduction

Nonalcoholic fatty liver disease (NAFLD) has been associated with greater cerebral white matter hyperintensity (WMH) volume and microbleeds. The adiponutrin (PNPLA3) rs738409 G variant, a robust NAFLD susceptibility variant, has been variably associated with carotid atherosclerosis. We hypothesized that this variant is associated with WMH volume, microbleeds, covert brain infarction (CBI), and small perivascular spaces.

Methods

We performed a cross-sectional analysis of the Northern Manhattan Study-MRI Substudy. The associations between the rs738409 G variant allele and outcomes were assessed using linear regression for WMH volume, logistic regression for microbleeds and CBI, and Poisson regression for small perivascular spaces. Models were adjusted for age, sex

SUBMITTER: Parikh NS 

PROVIDER: S-EPMC9004230 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature