Absolute configuration determination of pharmaceutical crystalline powders by MicroED via chiral salt formation.

ABSTRACT: Microcrystal electron diffraction (MicroED) has established its complementary role alongside X-ray diffraction in crystal structure elucidation. Unfortunately, kinematical refinement of MicroED data lacks the differentiation power to assign the absolute structure solely based on the measured intensities. Here we report a method for absolute configuration determination via MicroED by employing salt formation with chiral counterions.

SUBMITTER: Wang B 

PROVIDER: S-EPMC9004345 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature