The Structural Determinants of Intra-Protein Compensatory Substitutions.

ABSTRACT: Compensatory substitutions happen when one mutation is advantageously selected because it restores the loss of fitness induced by a previous deleterious mutation. How frequent such mutations occur in evolution and what is the structural and functional context permitting their emergence remain open questions. We built an atlas of intra-protein compensatory substitutions using a phylogenetic approach and a dataset of 1,630 bacterial protein families for which high-quality sequence alignments and experimentally derived protein structures were available. We identified more than 51,000 positions coevolving by the mean of predicted compensatory mutations. Using the evolutionary and structural properties of the analyzed positions, we demonstrate that compensatory mutations are scarce (typically o

SUBMITTER: Chaurasia S 

PROVIDER: S-EPMC9004419 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature