FcεR1-expressing nociceptors trigger allergic airway inflammation.

ABSTRACT:

Background

Lung nociceptor neurons amplify immune cell activity and mucus metaplasia in response to an inhaled allergen challenge in sensitized mice.

Objective

We sought to identify the cellular mechanisms by which these sensory neurons are activated subsequent to allergen exposure.

Methods

We used calcium microscopy and electrophysiologic recording to assess whether vagal neurons directly respond to the model allergen ovalbumin (OVA). Next, we generated the first nociceptor-specific FcεR1γ knockdown (TRPV1^Cre::FcεR1γ^fl/fl) mice to assess whether this targeted invalidation would affect the severity of allergic inflammation in response to allergen challenges.

Results

Lung-innervating jugular nodose complex ganglion neurons express the high-

SUBMITTER: Crosson T 

PROVIDER: S-EPMC9004488 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature