KLF11 deficiency enhances chemokine generation and fibrosis in murine unilateral ureteral obstruction.

ABSTRACT: Progression of virtually all forms of chronic kidney disease (CKD) is associated with activation of pro-inflammatory and pro-fibrotic signaling pathways. Despite extensive research, progress in identifying therapeutic targets to arrest or slow progression of CKD has been limited by incomplete understanding of basic mechanisms underlying renal inflammation and fibrosis in CKD. Recent studies have identified Kruppel-like transcription factors that have been shown to play critical roles in renal development, homeostasis, and response to injury. Although KLF11 deficiency has been shown to increase collagen production in vitro and tissue fibrosis in other organs, no previous study has linked KLF11 to the development of CKD. We sought to test the hypothesis that KLF11 deficiency promotes CKD thr

SUBMITTER: De Lorenzo SB 

PROVIDER: S-EPMC9004740 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature