Biochemical and proteomic analyses of venom from a new pit viper, Protobothrops kelomohy.

ABSTRACT:

Background

A new pit viper, Protobothrops kelomohy, has been recently discovered in northern and northwestern Thailand. Envenoming by the other Protobothrops species across several Asian countries has been a serious health problem since their venom is highly hematotoxic. However, the management of P. kelomohy bites is required as no specific antivenom is available. This study aimed to investigate the biochemical properties and proteomes of P. kelomohy venom (PKV), including the cross-neutralization to its lethality with antivenoms available in Thailand.

Methods

PKV was evaluated for its neutralizing capacity (ER₅₀), lethality (LD₅₀), procoagulant and hemorrhagic effects with three monovalent antivenoms (TAAV, DSAV, and CRAV)

SUBMITTER: Chanhome L 

PROVIDER: S-EPMC9005077 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature