Evaluating Vitamin C in Septic Shock: A Randomized Controlled Trial of Vitamin C Monotherapy.

ABSTRACT:

Objectives

To determine whether IV vitamin C therapy reduces 28-day mortality in patients with septic shock.

Design

Multicenter, double-blinded, randomized controlled trial.

Setting

One academic medical ICU and four community ICUs.

Patients

Of 167 adult patients within 24 hours of vasopressor initiation for septic shock, 126 consented to participation, and 124 received study drug and were included in analysis.

Interventions

IV vitamin C (10 mg/mL in normal saline) administered as a 1,000-mg bolus over 30 minutes followed by continuous infusion of 250 mg/hr for 96 hours or placebo of equal volumes of normal saline.

Measurements and main results

Of 124 subjects receiving study drug and included in analysis, 60 received vitamin C and 64 placebo. The

SUBMITTER: Wacker DA 

PROVIDER: S-EPMC9005102 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature