Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins.

ABSTRACT: Staphylococcus aureus (SA) leukocidin ED (LukED) belongs to a family of bicomponent pore forming toxins that play important roles in SA immune evasion and nutrient acquisition. LukED targets specific G protein-coupled chemokine receptors to lyse human erythrocytes (red blood cells) and leukocytes (white blood cells). The first recognition step of receptors is critical for specific cell targeting and lysis. The structural and molecular bases for this mechanism are not well understood but could constitute essential information to guide antibiotic development. Here, we characterized the interaction of LukE with chemokine receptors ACKR1, CCR2, and CCR5 using a combination of structural, pharmacological, and computational approaches. First, crystal structures of LukE in complex with a s

SUBMITTER: Lambey P 

PROVIDER: S-EPMC9005193 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature