[Intrinsically photosensitive retinal ganglion cells].

ABSTRACT:

Background

Melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGC) area third class of photoreceptors in the retina in addition to rods and cones. They are a small heterogeneous population of cells primarily mediating non-image-forming visual functions.

Objective

This article provides an overview of the current understanding of the functions and the diversity of ipRGCs. It moreover gives an insight into clinically and translationally relevant aspects and treatment options.

Material and methods

Narrative review article.

Results

ipRGCs make up ~1-2% of all retinal ganglion cells and are divided into 6 specialized subtypes. With the photopigment melanopsin they can trigger light responses without rod or cone input and can relay irradiance

SUBMITTER: Kinder L 

PROVIDER: S-EPMC9005408 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature