Tissue resident memory T cells inhabit the deep human conjunctiva.

ABSTRACT: Mucosal linings of the body, including the conjunctiva, are enriched in tissue-resident memory T cells (T_RMs) whose defining feature is their continual tissue protection that does not rely on migration to lymphoid organs to elicit immune responses. Hitherto, conjunctival T_RMs have only been identified in the superficial epithelium. This work aims to develop a more complete understanding of the conjunctival immunological capacity by investigating the presence of T_RMs within the deeper, more stable layers of the healthy human conjunctiva. Using immunofluorescence microscopy and antibodies against CD3, CD4, CD69 and HLA-DR on bulbar conjunctival biopsies obtained from 7 healthy adults (age range = 32-77 years; females = 4), we identified CD69⁺T

SUBMITTER: Arnous R 

PROVIDER: S-EPMC9005529 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature