Extracellular vesicles improve diastolic function and substructure in normal and high-fat diet models of chronic myocardial ischemia.

ABSTRACT:

Objective

The burden of mortality and morbidity of cardiovascular disease is in part due to substantial fibrosis accelerated by coexisting risk factors. This study aims to evaluate the effect of extracellular vesicle therapy on diastolic function and myocardial fibrosis in the setting of chronic myocardial ischemia with and without a high-fat diet.

Methods

Forty male Yorkshire swine were administered a normal or high-fat diet. At 11 weeks of age, they underwent placement of an ameroid constrictor on their left circumflex coronary artery. Both dietary groups then received either intramyocardial injection of vehicle saline as controls or extracellular vesicles as treatment into the ischemic territory (normal diet control, n = 8; high-fat diet controls, n = 11) or extracellular

SUBMITTER: Aboulgheit A 

PROVIDER: S-EPMC9005578 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature