Characterization of a castrate-resistant prostate cancer xenograft derived from a patient of West African ancestry.

ABSTRACT:

Background

Prostate cancer is a clinically and molecularly heterogeneous disease, with highest incidence and mortality among men of African ancestry. To date, prostate cancer patient-derived xenograft (PCPDX) models to study this disease have been difficult to establish because of limited specimen availability and poor uptake rates in immunodeficient mice. Ancestrally diverse PCPDXs are even more rare, and only six PCPDXs from self-identified African American patients from one institution were recently made available.

Methods

In the present study, we established a PCPDX from prostate cancer tissue from a patient of estimated 90% West African ancestry with metastatic castration resistant disease, and characterized this model's pathology, karyotype, hotspot mutations, copy num

SUBMITTER: Patierno BM 

PROVIDER: S-EPMC9005588 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature