Altered Structural Brain Network Topology in Patients With Primary Craniocervical Dystonia.

ABSTRACT:

Purpose

Regional cortical thickness or volume analyses based upon structural MRI scans have been employed to study the pathophysiology of primary craniocervical dystonia (CCD). In the present study, brain connectivity network analyses based upon morphological distribution similarities among different brain areas were used to study the network disruption in individuals affected by CCD.

Methods

The T1 MRI scans were completed for 37 patients with CCD and 30 healthy controls, with individual brain structural networks being constructed based upon gray matter (GM) similarities in 90 regions within the brain. Area under the curve (AUC) values for each network parameter were determined, and the GRETNA program was used to conduct a graph theory-based measurement of nodal and global

SUBMITTER: Wang X 

PROVIDER: S-EPMC9005792 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature