Natural Killer Cells Infiltration in the Joints Exacerbates Collagen-Induced Arthritis.

ABSTRACT:

Introduction

The role of natural killer (NK) cells in rheumatoid arthritis remains controversial. We aimed to assess the role of NK cells in the pathogenesis of rheumatoid arthritis.

Materials and methods

The percentage of NK cells in the peripheral blood, spleen, lymph nodes and inflamed paws from collagen-induced arthritis mice were examined through the disease progression. Correlation between the proportion of NK cells and subsets with arthritis score, histopathological changes, and bone destruction were evaluated. Adoptive cell transfer was performed to determine the effect of NKp46⁺NK cells on arthritis development, and the role of receptor NKp46 was explored with NKp46 knockout mice.

Results

The percentage of NK cells in peripheral blood decreased at

SUBMITTER: Wu L 

PROVIDER: S-EPMC9005809 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature