Establishment of Reference Interval and Aging Model of Homocysteine Using Real-World Data.

ABSTRACT:

Objective

The level of Homocysteine (Hcy) in males is generally higher than that of females, but the same reference interval (RI) is often used in clinical practice. This study aims to establish a sex-specific RI of Hcy using five data mining algorithms and compare these results. Furthermore, age-related continuous RI was established in order to show the relationship between Hcy concentration distribution and age.

Methods

A total of 20,801 individuals were included in the study and Tukey method was used to identify outliers in subgroups by sex and age. Multiple linear regression and standard deviation ratio (SDR) was used to determine whether the RI for Hcy needs to be divided by sex and age. Five algorithms including Hoffmann, Bhattacharya, expectation maximization (EM), ko

SUBMITTER: Ma C 

PROVIDER: S-EPMC9005842 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature