Insights Into the Role of Heat Shock Protein 27 in the Development of Neurodegeneration.

ABSTRACT: Small heat shock protein 27 is a critically important chaperone, that plays a key role in several essential and varied physiological processes. These include thermotolerance, apoptosis, cytoskeletal dynamics, cell differentiation, protein folding, among others. Despite its relatively small size and intrinsically disordered termini, it forms large and polydisperse oligomers that are in equilibrium with dimers. This equilibrium is driven by transient interactions between the N-terminal region, the α-crystallin domain, and the C-terminal region. The continuous redistribution of binding partners results in a conformationally dynamic protein that allows it to adapt to different functions where substrate capture is required. However, the intrinsic disorder of the amino and carboxy terminal regio

SUBMITTER: Holguin BA 

PROVIDER: S-EPMC9005852 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature