Interstitial Lung Abnormalities, Emphysema, and Spirometry in Smokers.

ABSTRACT:

Background

Most pulmonary conditions reduce FVC, but studies of patients with combined pulmonary fibrosis and emphysema demonstrate that reductions in FVC are less than expected when these two conditions coexist clinically.

Research question

Do interstitial lung abnormalities (ILAs), chest CT imaging findings that may suggest an early stage of pulmonary fibrosis in individuals with undiagnosed disease, affect the association between emphysema and FVC?

Study design and methods

Measures of ILA and emphysema were available for 9,579 and 5,277 participants from phases 1 (2007-2011) and 2 (2012-2016) of the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease Study (COPDGene), respectively. ILA were defined by Fleischner Society guidelines. Adjusted linear regress

SUBMITTER: Menon AA 

PROVIDER: S-EPMC9005862 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature