Significance of FEV₃/FEV₆ in Recognition of Early Airway Disease in Smokers at Risk of Development of COPD: Analysis of the SPIROMICS Cohort.

ABSTRACT:

Background

Small airways are known to be affected early in the course of COPD; however, traditional spirometric indices may not accurately identify small airways disease.

Research question

Can forced expiratory volume in 3 s/forced expiratory volume in 6 s (FEV₃/FEV₆) identify early airflow abnormalities and predict future clinically important respiratory-related outcomes, including development of COPD?

Study design and methods

The study included 832 current and former smokers with post-bronchodilator FEV₁/FVC ≥ 0.7 from the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) cohort. Participants were classified as having a reduced pre-bronchodilator FEV₃/FEV₆ based on lower limit of normal

SUBMITTER: Yee N 

PROVIDER: S-EPMC9005864 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature