Automated Synthesis of ¹⁸F-BCPP-EF {2-tert-Butyl-4-Chloro-5-{6-[2-(2[¹⁸F]fluoroethoxy)-Ethoxy]-Pyridin-3-ylmethoxy}-2H-Pyridazin-3-One for Imaging of Mitochondrial Complex 1 in Parkinson's Disease.

ABSTRACT: Mitochondrial complex I (MC-I) is an essential component of brain bioenergetics and can be quantified and studied using positron emission tomography (PET). A specific high affinity ¹⁸F radiotracer for MC-I enables monitoring of neurodegenerative disease progression and pathology via PET imaging. To facilitate clinical research studies tracking MC-I activity in Parkinson's disease and other neurodegenerative diseases, a fully automated synthesis of the recently described 2-tert-butyl-4-chloro-5-{6-[2-(2[¹⁸F]fluoroethoxy)-ethoxy]-pyridin-3-ylmethoxy}-2H-pyridazin-3-one ([¹⁸F] BCPP-EF, [ ¹⁸ F]1) was developed. We report the first automated synthesis [¹⁸F]BCPP-EF using a green radiochemistry approa

SUBMITTER: Kaur T 

PROVIDER: S-EPMC9005973 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature