The aldehyde hypothesis: metabolic intermediates as antimicrobial effectors.
Ontology highlight
ABSTRACT:
SUBMITTER: Darwin KH
PROVIDER: S-EPMC9006002 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Publications
The aldehyde hypothesis: metabolic intermediates as antimicrobial effectors.
Darwin K Heran KH Stanley Sarah A SA
Open biology 20220413 4
There are many reactive intermediates found in metabolic pathways. Could these potentially toxic molecules be exploited for an organism's benefit? We propose that during certain microbial infections, the production of inherently reactive aldehydes by an infected host is a previously unappreciated innate immune defence mechanism. While there has been a significant focus on the effects of aldehydes on mammalian physiology, the idea that they might be exploited or purposefully induced to kill patho ...[more]
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