Association of mid-life serum lipid levels with late-life brain volumes: The atherosclerosis risk in communities neurocognitive study (ARICNCS).

ABSTRACT:

Background

Limited information exists regarding the association between midlife lipid levels and late-life total and regional brain volumes.

Methods

We studied 1872 participants in the longitudinal community-based Atherosclerosis Risk in Communities Neurocognitive Study. Serum lipid levels were measured in 1987-1989 (mean age, 53 ± 5 years). Participants underwent 3T brain MRI scans in 2011-2013. Brain volumes were measured using FreeSurfer image analysis software. Linear regression models were used to assess the associations between serum lipids and brain volumes modeled in standard deviation (SD) units, adjusting for potential confounders.

Results

In adjusted analyses, one SD higher low-density lipoprotein cholesterol (LDL) levels were associated with larger total b

SUBMITTER: Moazzami K 

PROVIDER: S-EPMC9006082 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature