Immunogenicity and Risk Factors Associated With Poor Humoral Immune Response of SARS-CoV-2 Vaccines in Recipients of Solid Organ Transplant: A Systematic Review and Meta-Analysis.

ABSTRACT:

Importance

Recipients of solid organ transplant (SOT) experience decreased immunogenicity after COVID-19 vaccination.

Objective

To summarize current evidence on vaccine responses and identify risk factors for diminished humoral immune response in recipients of SOT.

Data sources

A literature search was conducted from existence of database through December 15, 2021, using MEDLINE, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov.

Study selection

Studies reporting humoral immune response of the COVID-19 vaccines in recipients of SOT were reviewed.

Data extraction and synthesis

Two reviewers independently extracted data from each eligible study. Descriptive statistics and a random-effects model were used. This report was prepared following th

SUBMITTER: Manothummetha K 

PROVIDER: S-EPMC9006106 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature