Automated sleep state classification of wide-field calcium imaging data via multiplex visibility graphs and deep learning.

ABSTRACT:

Background

Wide-field calcium imaging (WFCI) allows for monitoring of cortex-wide neural dynamics in mice. When applied to the study of sleep, WFCI data are manually scored into the sleep states of wakefulness, non-REM (NREM) and REM by use of adjunct EEG and EMG recordings. However, this process is time-consuming and often suffers from low inter- and intra-rater reliability and invasiveness. Therefore, an automated sleep state classification method that operates on WFCI data alone is needed.

New method

A hybrid, two-step method is proposed. In the first step, spatial-temporal WFCI data is mapped to multiplex visibility graphs (MVGs). Subsequently, a two-dimensional convolutional neural network (2D CNN) is employed on the MVGs to be classified as wakefulness, NREM and REM.

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9006179 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature